Biventricular Tissue Phase Mapping
Tissue Phase Mapping (TPM) is a well-established technique to quantify three-directional myocardial velocities and has been successfully used for the detection of regional left ventricular abnormalities in cardiac pathologies such as hypertensive heart disease, nonischemic cardiomyopathy, or after heart transplantation. So far, TPM has been rarely applied to the right ventricle, although the assessment of both left and right ventricular motion is important for the understanding of the impact of heart disease on regional functional abnormalities of both cardiac chambers.
Recently, we have extended the TPM analysis to the right ventricle to obtain biventricular myocardial velocities and to quantify ventricular interactions. Our analysis includes the assessment of LV and RV peak velocities mapped to an extended 16+10 AHA segment model, LV and RV velocity twist, as well as cross-correlation coefficients to quantify inter-ventricular dyssynchrony. First clinical applications of this novel analysis were pediatric patients with repaired tetralogy of Fallot and both pediatric and adult patients after heart transplantation.
Moreover, markers of myocardial function such as TPM velocities can be combined with structural measurements such as T1 and T2 mapping to enable the detection of structure-function abnormalities in various heart diseases. See for example our research page on Heart Failure and Cardiac Transplant.
Investigators: Michael Markl (PhD), James Carr (MD), Kai Lin (MD), Jeremy Collins (MD), Alexander Ruh (PhD)
Funding: National Heart, Lung, And Blood Institute of the NIH (NHLBI)
Publications: